Elucida Oncology, Inc., a Cornell/MSK start-up commercializing C dots has successfully filled vials with a therapeutic Cornell dot (C dot) drug product (DP) for clinical use. This is an important milestone for Elucida Oncology, Inc, on their way to the first human clinical trials in the second half of 2021 using C dots as drug delivery vehicles for therapeutic agents.
C Dots were created more than 15 years ago in the lab of Uli Wiesner, the Spencer T. Olin Professor of Engineering in the Department of Materials Science and Engineering. Wiesner has been working to put C Dots to use in the fight against cancer ever since. As a result of their size, C Dots proved safe and effective for use in humans as both an imaging and a diagnostic tool in early and advanced clinical trials.
The first photo to the left may remind everyone of the images we have all seen of the Covid vaccines being filled into small vials for end use in humans. This is exactly the same filling process, except with solutions including therapeutic C dots. These solutions are blue, as C dots incorporate a fluorescent dye absorbing in the near-infrared (NIR) part of the optical spectrum. The visible blue color is the complementary color to that NIR absorption.
Not only did this product arise from MSE research but several MSE alums currently work for Elucida. In the second photo below, three are former MSE graduate students/alumni. These are (from left to right, with roles at Elucida): Kai Ma, CTO (MSE Ph.D. Wiesner group), Fei Wu, Principle Scientist (MSE Ph.D. Delphine Gourdon group), Melik Turker, Principle Scientist (MSE Ph.D. Wiesner group), and Aranapakam Venkatesan, Ph.D., VP Chemistry (Elucida).
"It is very exciting to see a product first developed in the lab
at the 10 ml scale to now being scaled up under GMP manufacturing standards and ready to go for the first therapeutic human clinical trial, with former MSE Ph.D. students paving the way,” said Uli Wiesner when looking at these images. Please go to these webpages for more information: https://wiesner.mse.cornell.edu/ and https://www.elucidaoncology.com/.
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